Genipin(structure on the top) is an aglycone derived from an iridoid glycoside called Geniposide (structure on the bottom) present in fruit of Gardenia jasmindides Ellis. Genipin is an excellent natural cross-linker for protein, collagen, gelatin, and chitosan cross-linking. It has a low acute toxicity, with LD50 i.v. 382 mg/kg in mice, therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking regents. It is also used for pharmaceutical purposes, such as choleretic action for liver diseases control.

CBC Genipin is in a white crystal powder form, with its purity 98% up by HPLC method. It is soluble in Ethanol, Methanol, Acetone, and slightly soluble in water. Currently there are many medical research groups conducting experiments on the use and effects of Genipin as a natural cross-linker. We believe in the near future Genipin will be an effective pharmaceutical raw material that will significantly benefit patients who need it.

CBC Genipin has been used by more than 220 research institutes in over 52 nations on applications spanning organ transplant, blood substitutes, glaucoma treatment, molecular imprint, and so on. Here are just a few universities/research institutes that have used our Genipin for research:

• USA: Stanford University, UC Berkeley, Massachusetts Institute of Technology, UCLA, University of Washington, University of Pennsylvania, USC, Columbia University, Lawrence Berkeley Lab, UT Austin, University of Illinois at Chicago, USDA, University of Colorado, Case Western Reserve University.
• CANADA: University of Toronto, Queens University, Ryerson University, McGill University, University of Saskatchewan, University of Western Ontario, Royal Canadian Mounted Police.
• UK: University of Cambridge, University of Bristol, The University of Manchester, Loughborough University.
• TAIWAN: National Taiwan University, National Tsing-Hua University, National Chiao Tung University, National Chung Cheng University, China Medical University, National Chung Hsing University...etc. （臺灣大學 ,清華大學 ,交通大學 ,成功大學,中央大學,中興大學 ,臺灣科技大學 ,臺灣海洋大學,中國醫藥大學, 陽明大學 ,中正大學,中原大學,臺北科技大學 ,雲林科技大學 ,嘉義大學 ,聯合大學 ,大葉大學 ,亞東技術學院 ,長榮大學 ,...等）
• EU: Universite catholique de Louvain, Aarhus Univesity Hospital, VTT Technical Research Centre, Institut National de la Recherche Agronomique, University of Lyon, University of Poitiers, University College Dublin, Forensic Science Northern Ireland Seapark, University of Pisa, University of Bologna, Politecnico di Torino, Politecnico di Milano, University of Florence, University of Oslo, Gdansk University of Technology, Jagiellonian University, Linkopings Universitet, University Hospital Balgrist, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC),Parque Cientifico Universidad de Valencia,University of Santiago de Compostela, Universidade de Aveiro, Universidade de Coimbra.
• ASIA: Silpakorn University, Mahasarakham University, Chulalongkorn University, Ateneo de Manila University, Mapua Institute of Technology, National Academy of Sciences of Ukraine, National University of Singapore, Nanyang Technological University, Universiti Putra Malaysia, Universiti Teknologi Malaysia, Indian Institutes of Technology, Tezpur University, Tehtan University.
• OTHERS: University of Wollongong, Deakin University, University of New South Wales, Australian Nuclear Science and Technology Organisation, University Melbourne, University of Auckland, Hebrew University of Jerusalem, University of the Witwatersrand, University of Cape Town, Federal University of Santa Catarina, Universidade Federal do Rio Grande do Norte, Fedetral University of Minas Gerais, Universidade de Sao Paulo, National University of Colombia.

Due to the constantly increasing number of publications, please use Google Scholar to search for related papers online:

Professor Hsing-Wen Sung of the National Tsing-Hua University in Taiwan have had a long collaboration with Challenge Bioproducts in developing Genipin, mainly for its application as a cross-linker.